Hepatoprotective effect of royal jelly, grape seed extract, and Lycium barbarum against diethylnitrosamine-induced liver toxicity in rats

Basit Öğe Kaydı
dc.contributor.authorSedat Bilgic
dc.contributor.authorZumrut Dogan
dc.contributor.authorSebile Azirak
dc.contributor.authorMehmet Erman Erdemli
dc.contributor.authorMuhittin Onderci
dc.contributor.authorAhmet Turk
dc.contributor.authorMehmet Kaya Ozer
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractAim: We aimed to investigate, the effects of royal jelly (RJ), grape seed extract (GSE), and Lycium barbarum extract (LBAE) against diethylnitrosamine (DEN) induced hepatotoxicity, in experimental animal model. Material and Methods: Fifty female Sprague Dawley rats were divided into five groups (n=10): Control, DEN, DEN+RJ, DEN+GSE, DEN+LBAE. DEN administrated groups were intraperitoneally (i.p.) injected with three separate administration of DEN (200 mg/kg), on the zero, fifteenth and thirtieth treatment day. Then 100 mg/kg of RJ was given to DEN+RJ group, 100 mg/kg of GSE was given to DEN+GSE group, and 400 mg/kg LBAE was given to DEN+LBAE group with the daily drinking water from day 0 for 16 weeks. Histopathologic alterations including apoptotic changes of liver were evaluated. Results: RJ, GSE, and LBAE treatments significantly reduced weight loss induced by DEN. DEN administrated rats significantly increases malondialdehyde (MDA) level. It also efficiently decreases glutathione (GSH) level and catalase (CAT), superoxide dismutase (SOD) activity. These results were significantly ameliorated by dietary supplements (p<0.05). In addition, they increased the total antioxidant status (TAS) level and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transpeptidase (GGT) levels significantly (p<0.05). TUNEL positive cells were extremly pervasive in the livers of DEN group. Conclusion: Improvements were prominent in case of RJ > GSE > LBAE. Our results indicated that RJ, GSE and LBAE might be useful for prevention of hepatotoxicity induced by DEN via ameliorative effects on biochemical and oxidative stress indices.
dc.identifier.endpage348
dc.identifier.issn2636-7688
dc.identifier.issue3
dc.identifier.startpage342
dc.identifier.trdizinid285605
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpnMU5qQTFOUT09
dc.identifier.urihttps://hdl.handle.net/11480/2361
dc.identifier.volume25
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectAnatomi ve Morfoloji
dc.subjectPeriferal Damar Hastalıkları
dc.subjectKalp ve Kalp Damar Sistemi
dc.subjectSolunum Sistemi
dc.subjectİmmünoloji
dc.subjectDermatoloji
dc.subjectGöz Hastalıkları
dc.subjectPatoloji
dc.subjectKlinik Nöroloji
dc.subjectOdyoloji ve Konuşma-Dil Patolojisi
dc.subjectNörolojik Görüntüleme
dc.subjectRadyoloji
dc.subjectNükleer Tıp
dc.subjectTıbbi Görüntüleme
dc.subjectAcil Tıp
dc.subjectTransplantasyon
dc.subjectEnfeksiyon Hastalıkları
dc.subjectHalk ve Çevre Sağlığı
dc.subjectTıbbi İnformatik
dc.subjectGeriatri ve Gerontoloji
dc.subjectNörolojik Bilimler
dc.subjectHematoloji
dc.subjectTıbbi Laboratuar Teknolojisi
dc.subjectAdli Tıp
dc.subjectTıbbi Etik
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectGastroenteroloji ve Hepatoloji
dc.subjectTemel Sağlık Hizmetleri
dc.subjectCerrahi
dc.subjectHücre Biyolojisi
dc.subjectOrtopedi
dc.subjectGenel ve Dahili Tıp
dc.subjectPediatri
dc.subjectTamamlayıcı ve Entegre Tıp
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectBiyokimyasal Araştırma Metotları
dc.subjectKulak
dc.subjectBurun
dc.subjectBoğaz
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectPsikiyatri
dc.subjectBiyofizik
dc.subjectYoğun Bakım
dc.subjectTıp
dc.subjectFizyoloji
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectAndroloji
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectGelişim Biyolojisi
dc.subjectGerontoloji
dc.subjectAnestezi
dc.subjectRehabilitasyon
dc.subjectOnkoloji
dc.subjectMikrobiyoloji
dc.subjectSpor Bilimleri
dc.subjectAlerji
dc.subjectTropik Tıp
dc.subjectÜroloji ve Nefroloji
dc.subjectRomatoloji
dc.titleHepatoprotective effect of royal jelly, grape seed extract, and Lycium barbarum against diethylnitrosamine-induced liver toxicity in rats
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu