Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and Iron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19

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dc.authoridIBRAHIM, Bashar/0000-0003-3086-0995
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorBayraktar, Mustafa
dc.contributor.authorOzturk, Ali
dc.contributor.authorIbrahim, Bashar
dc.date.accessioned2024-11-07T13:34:19Z
dc.date.available2024-11-07T13:34:19Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractOur study aims to determine the relationship between hepcidin, aquaporin (AQP-1), copper (Cu), zinc (Zn), iron (Fe) levels, and oxidative stress in the sera of seriously ill COVID-19 patients with invasive mechanical ventilation. Ninety persons with and without COVID-19 were taken up and separated into two groups. The first group included seriously COVID-19 inpatients having endotracheal intubation in the intensive care unit (n = 45). The second group included individuals who had negative PCR tests and had no chronic disease (the healthy control group n = 45). AQP-1, hepcidin, Zn, Cu, Fe, total antioxidant status (TAS), and total oxidant status (TOS) were studied in the sera of both groups, and the relations of these levels with oxidative stress were determined. When the COVID-19 patient and the control groups were compared, all studied parameters were found to be statistically significant (p < 0.01). Total oxidant status (TOS), oxidative stress index (OSI), and AQP-1, hepcidin, and Cu levels were increased in patients with COVID-19 compared to healthy people. Serum TAC, Zn, and Fe levels were found to be lower in the patient group than in the control group. Significant correlations were detected between the studied parameters in COVID-19 patients. Results indicated that oxidative stress may play an important role in viral infection due to SARS-CoV-2. We think that oxidative stress parameters as well as some trace elements at the onset of COVID-19 disease will provide a better triage in terms of disease severity.
dc.identifier.doi10.1007/s12011-022-03400-6
dc.identifier.endpage5021
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue12
dc.identifier.pmid36001235
dc.identifier.scopus2-s2.0-85136966133
dc.identifier.scopusqualityQ1
dc.identifier.startpage5013
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03400-6
dc.identifier.urihttps://hdl.handle.net/11480/15916
dc.identifier.volume200
dc.identifier.wosWOS:000843981000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCOVID-19
dc.subjectOxidative stress
dc.subjectTotal antioxidant status
dc.subjectTotal oxidant status
dc.subjectTrace elements
dc.subjectAquaporin
dc.subjectHepcidin
dc.titleEvaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and Iron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19
dc.typeArticle

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