Epoxyeicosatrienoic acid Metabolism in Preeclampsia
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Preeclampsia (PE) is a disease that characterized by hypertension and proteinuria during pregnancy.Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites which have vasodilatator, anti-inflammatory andprofibrinolytic effects. Soluble epoxide hydrolase (sEH; EC 3.3.3.2) catalyses the degradation of EETs to their inactivediols (DHETs). Low circulating levels of EETs may be related to high blood pressure in preeclampsia. The aim of thisstudy is to determine the level of 11,12-DHETs, a representative metabolite of sEH-mediated metabolism of EET, inpreeclamptic patients.Method: 11,12-DHET levels were measured by ELISA in plasma samples of 75 PE patients and 75 normotensivepregnant women as controls.Results: It was found that lasma 11,12-DHET levels of PE patients was significantly increased compared to the controlgroup (p <0.05).Conclusions: These results and our previous findings suggest that high sEH activities in PE patients may cause toproduce more 11,12-DHETs in PE. sEH enzyme with high catalytic activity may play a role in the pathogenesis of PEby contributing to the reduction of vasodilatator, anti-hypertensive and anti-inflammatory effects of EETs by rapiddegradation of these molecules.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Cumhuriyet Tıp Dergisi (ELEKTRONİK)
WoS Q Değeri
Scopus Q Değeri
Cilt
40
Sayı
4
