Epoxyeicosatrienoic acid Metabolism in Preeclampsia

Küçük Resim Yok

Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objective: Preeclampsia (PE) is a disease that characterized by hypertension and proteinuria during pregnancy.Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites which have vasodilatator, anti-inflammatory andprofibrinolytic effects. Soluble epoxide hydrolase (sEH; EC 3.3.3.2) catalyses the degradation of EETs to their inactivediols (DHETs). Low circulating levels of EETs may be related to high blood pressure in preeclampsia. The aim of thisstudy is to determine the level of 11,12-DHETs, a representative metabolite of sEH-mediated metabolism of EET, inpreeclamptic patients.Method: 11,12-DHET levels were measured by ELISA in plasma samples of 75 PE patients and 75 normotensivepregnant women as controls.Results: It was found that lasma 11,12-DHET levels of PE patients was significantly increased compared to the controlgroup (p <0.05).Conclusions: These results and our previous findings suggest that high sEH activities in PE patients may cause toproduce more 11,12-DHETs in PE. sEH enzyme with high catalytic activity may play a role in the pathogenesis of PEby contributing to the reduction of vasodilatator, anti-hypertensive and anti-inflammatory effects of EETs by rapiddegradation of these molecules.

Açıklama

Anahtar Kelimeler

Genel ve Dahili Tıp

Kaynak

Cumhuriyet Tıp Dergisi (ELEKTRONİK)

WoS Q Değeri

Scopus Q Değeri

Cilt

40

Sayı

4

Künye