Epoxyeicosatrienoic acid Metabolism in Preeclampsia

Basit Öğe Kaydı
dc.contributor.authorSarı, İsmail
dc.contributor.authorPınarbaşı, Hatice
dc.contributor.authorYıldız, Çağlar
dc.date.accessioned2024-11-07T13:19:34Z
dc.date.available2024-11-07T13:19:34Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Preeclampsia (PE) is a disease that characterized by hypertension and proteinuria during pregnancy.Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites which have vasodilatator, anti-inflammatory andprofibrinolytic effects. Soluble epoxide hydrolase (sEH; EC 3.3.3.2) catalyses the degradation of EETs to their inactivediols (DHETs). Low circulating levels of EETs may be related to high blood pressure in preeclampsia. The aim of thisstudy is to determine the level of 11,12-DHETs, a representative metabolite of sEH-mediated metabolism of EET, inpreeclamptic patients.Method: 11,12-DHET levels were measured by ELISA in plasma samples of 75 PE patients and 75 normotensivepregnant women as controls.Results: It was found that lasma 11,12-DHET levels of PE patients was significantly increased compared to the controlgroup (p <0.05).Conclusions: These results and our previous findings suggest that high sEH activities in PE patients may cause toproduce more 11,12-DHETs in PE. sEH enzyme with high catalytic activity may play a role in the pathogenesis of PEby contributing to the reduction of vasodilatator, anti-hypertensive and anti-inflammatory effects of EETs by rapiddegradation of these molecules.
dc.identifier.doi10.7197/223.vi.437122
dc.identifier.endpage460
dc.identifier.issn1305-0028
dc.identifier.issue4
dc.identifier.startpage454
dc.identifier.trdizinid321951
dc.identifier.urihttps://doi.org/10.7197/223.vi.437122
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/321951
dc.identifier.urihttps://hdl.handle.net/11480/13191
dc.identifier.volume40
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Tıp Dergisi (ELEKTRONİK)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectGenel ve Dahili Tıp
dc.titleEpoxyeicosatrienoic acid Metabolism in Preeclampsia
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu