Frequency of thiopurine S-methyltransferase gene variations in turkish children with acute leukemia
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Journal of Pediatrics
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study we aim to determine the genotype distribution and allele frequencies of common TPMT (*2, *3A, *3B and *3C) polymorphisms in Turkish children with acute leukemia. The study population consisted of 169 patients aged between 1 and 15 years who were admitted to Losante Pediatric Hematology and Children’s Hospital with the diagnosis of acute leukemia. Genotyping of TPMT polymorphisms was screened with real-time PCR using fluorescence melting curve detection analysis. We found that the frequencies of four allelic variants of TPMT are *2 (238 G>C) (0,0%), *3A (460G>A and 719A>G) (1.7%), *3B (460G>A) (1,7%) and *3C (719A>G) (2.4%). Frequency of TPMT alleles increases the efficacy of leukemia treatment. Thus, TPMT genotyping can be useful for optimizing 6-MP therapy. © 2018, Turkish Journal of Pediatrics. All rights reserved.
Açıklama
Anahtar Kelimeler
Childhood, Leukemia, Polymorphism, TPMT
Kaynak
Turkish Journal of Pediatrics
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
60
Sayı
2
